Evidence map›Paper›PMID 42282739›Full record

ArticlebioRxiv : the preprint server for biology2026

Critical illness expands a transcriptionally distinct hypometabolic CD8

Casey M Nichols, Erin L Mwizerwa, Chooi Ying Sim, Sarah N Obeidalla, Jacqueline-Yvonne Cephus, Caroline E Roe, Jonathon M Irish, Dawn C Newcomb, V Eric Kerchberger, Julie A Bastarache and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Casey M NicholsDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0000-5470-9558
Erin L MwizerwaDivision of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Chooi Ying SimDivision of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah N ObeidallaDivision of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jacqueline-Yvonne CephusDivision of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Caroline E RoeDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Jonathon M IrishDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-9428-8866
Dawn C NewcombDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-2592-9433
V Eric KerchbergerDivision of Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-0342-1965
Julie A BastaracheDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-0458-6507
Jeffrey C RathmellBen May Department of Cancer Research, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-4106-3396
Lorraine B WareDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-9429-4702
Matthew T StierDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-3928-1682

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Single Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1M
NRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6M
The Sepsis ClinicAl Resource And Biorepository (SCARAB) ProjectR33GM144915 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, JULIE A., WARE, LORRAINE B · 2024 to 2025
$1.5M
Tissue-specific functional genomics in the acute respiratory distress syndromeK01HL157755 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KERCHBERGER, VERN ERIC · 2021 to 2025
$845k
Immunometabolic Regulation of CD8 T Cell Dynamics in Human Critical Illness and SepsisK08GM163052 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Matthew T. Stier · 2026 to 2026
$186k
NCATS NIH HHS TL1 TR002244NCI NIH HHS R01 CA226833NHLBI NIH HHS K01 HL157755NIGMS NIH HHS K08 GM163052NIGMS NIH HHS R33 GM144915NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Immune dysfunction is a major driver of morbidity and mortality in critical illness syndromes including sepsis. Specifically, CD8

Identifiers

PMID42282739
PMCPMC13252141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.