Evidence map›Paper›PMID 42282733›Full record

ArticlebioRxiv : the preprint server for biology2026

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism.

Hiba Douja Chehade, Daniil Berezhnoi, Samhitha Somavarapu, Zihang Wang, Jitong Jiang, Liqiang Chen, Benjamin B Risk, Thomas Wichmann, Hong-Yuan Chu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiba Douja ChehadeDepartment of Pharmacology and Physiology, Georgetown University, Washington, D.C., United States.ORCID 0000-0002-5959-7900
Daniil BerezhnoiDepartment of Pharmacology and Physiology, Georgetown University, Washington, D.C., United States.ORCID 0000-0001-7507-0589
Samhitha SomavarapuDepartment of Pharmacology and Physiology, Georgetown University, Washington, D.C., United States.
Zihang WangDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States.
Jitong JiangDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States.
Liqiang ChenDepartment of Pharmacology and Physiology, Georgetown University, Washington, D.C., United States.
Benjamin B RiskDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States.ORCID 0000-0003-1090-0777
Thomas WichmannDepartment of Neurology, School of Medicine, Emory University, Atlanta, GA, United States.ORCID 0000-0002-2751-9545
Hong-Yuan ChuDepartment of Pharmacology and Physiology, Georgetown University, Washington, D.C., United States.ORCID 0000-0003-0923-683X

Funding

Motor cortical circuitry adaptations in experimental Parkinson's diseaseR01NS121371 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI CHU, HONG-YUAN · 2021 to 2025
$2.2M
Targeted Cortical Circuit Manipulation in Parkinson's DiseaseR21NS135545 · NINDS · VAN ANDEL RESEARCH INSTITUTE · PI CHU, HONG-YUAN, HOCHGESCHWENDER, UTE H · 2023 to 2023
$485k
NINDS NIH HHS R01 NS121371NINDS NIH HHS R21 NS135545
6 · The paper itself

Abstract

There are substantial functional changes in the primary motor cortex (M1) in Parkinson's disease (PD). However, the temporal relationship between midbrain dopaminergic (DA) neurodegeneration, M1 circuit dysfunction, and Parkinsonian motor symptoms remains poorly understood. Using a genetic mouse model of progressive nigrostriatal DA degeneration ("MitoPark" mice), we determine the time course of M1 cellular dysfunction and skilled movement impairment as the midbrain DA neurons gradually degenerate. M1 pyramidal neuronal subtypes were identified using AAV-mediated retrograde labeling. During progressive DA loss, MitoPark mice developed gradually impaired performance in a reach-to-grasp single-food-pellet task. These impairments were detectable at a moderate motor stage of Parkinsonism.

Identifiers

PMID42282733
PMCPMC13252005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.