Evidence map›Paper›PMID 42282710›Full record

ArticlebioRxiv : the preprint server for biology2026

An Itch Receptor Drives Melanoma.

Naina Gour, Aishwarya Atakkatan, Moloud Akbarzadeh, Hwan Mee Yong, Aishwarya Magesh, Zhiping Wu, Hyunkeun Joo, Yash Chhabra, Junmin Peng, Ashani Weeraratna and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Naina GourSolomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Aishwarya AtakkatanDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Moloud AkbarzadehCentre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval (IUCPQ-ULaval), Université Laval, Québec, QC, Canada.
Hwan Mee YongDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Aishwarya MageshDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Zhiping WuDepartments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hyunkeun JooSolomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Yash ChhabraDepartment of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ashani WeeraratnaDepartment of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mathieu LaplanteCentre de recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval (IUCPQ-ULaval), Université Laval, Québec, QC, Canada.ORCID 0000-0002-1752-6741
Stephane LajoieDepartment of Otolaryngology, Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Xinzhong DongSolomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9750-7718

Funding

Functional Analysis of Mrgpr Family in itch sensationR37NS054791 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Xinzhong Dong · 2022 to 2026
$2.9M
Neuronally-driven accumulation of glycolytic MafB+MHCIIhi IMs drive airway allergyR01AI170709 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Stephane Lajoie · 2023 to 2026
$2.5M
Confocal microscope for a live cell imaging facility at biosafety level 2S10OD036404 · OD · JOHNS HOPKINS UNIVERSITY · PI HAMACHER-BRADY, ANNE · 2024 to 2024
$750k
NIAID NIH HHS R01 AI170709NIH HHS S10 OD036404NINDS NIH HHS R37 NS054791
6 · The paper itself

Abstract

Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch. Here, we identify MRGPRX4 as an unexpected melanoma driver. MRGPRX4 is upregulated in melanoma and is confined to invasive, neural-crest-like and pre-EMT states associated with dedifferentiation and therapy resistance. Ectopic MRGPRX4 expression in mouse melanocytes drives 100% penetrant, highly metastatic melanoma, demonstrating oncogenic behavior. MRGPRX4 promotes melanoma cell proliferation and invasion through basal, ligand-independent, PI3K-AKT-MAPK activation. Multi-omics links MRGPRX4 expression to a mesenchymal/neural-crest-like program that defines a distinct invasive MRGPRX4

Identifiers

PMID42282710
PMCPMC13251912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.