Evidence map›Paper›PMID 42282692›Full record

ArticlebioRxiv : the preprint server for biology2026

Beta-Adrenergic Stimulation and

Paul Heinrich, Raina M Jung, Jonathan S Achter, Vincent X Nguyen, Carissa A Lee, Carolin Sailer, Henna Domian, Alison Vander Roest, Fabian P Suchy, James W Jahng and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Paul HeinrichStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-4899-8343
Raina M JungStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Jonathan S AchterDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vincent X NguyenStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Carissa A LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Carolin SailerDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Henna DomianStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Alison Vander RoestDepartment of Pediatrics (Cardiology), Stanford University School of Medicine, Stanford, CA 94305.
Fabian P SuchyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
James W JahngStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Ana KojicStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Daniel LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Amelie PaascheStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Brock RobertsAllen Institute for Cell Science, Seattle, WA 98109.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Han ZhuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2751-7814
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Daniel BernsteinStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Alessandra MorettiRegenerative Medicine in Cardiovascular Diseases, First Department of Medicine (Cardiology), TUM University Hospital Rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Germany.ORCID 0000-0001-5782-7832
Alicia LundbyDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Soah LeeDepartment of Biopharmaceutical Convergence, Sungkyunkwan University School of Pharmacy, Suwon, Gyeoniggi-do 16419, South Korea.ORCID 0000-0001-7613-592X
Sean M WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic heart disorder, characterized by significant phenotypic variability even among individuals with identical Methods and Results: Isogenic hiPSCs with Conclusions: Our study highlights the use of a variably penetrant MYH7 mutation to investigate factors that influence HCM phenotype penetrance. Specifically, we found that mutant gene dosage and beta-adrenergic stimulation induce distinct HCM disease phenotypes, providing novel insights into mechanisms that may contribute to variable disease expression in HCM.

Indexed as

Hypertrophic CardiomyopathyiPSC-derived CardiomyocytesVariable Disease Penetrance

Identifiers

PMID42282692
PMCPMC13252407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.