Evidence map›Paper›PMID 42282678›Full record

ArticlebioRxiv : the preprint server for biology2026

Precise calcium-to-spike inference using biophysical generative models.

Gerard Joey Broussard, Giovanni Diana, Francisco J Urra Quiroz, B Semihcan Sermet, Nelson Rebola, Sanjeev Janarthanan, Laura A Lynch, David M Turner, David A DiGregorio, Samuel S-H Wang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gerard Joey BroussardNeuroscience Institute, 40 Woodlands Way, Princeton University, Princeton, New Jersey USA 08540.ORCID 0000-0003-1636-2615
Giovanni DianaInstitut Pasteur, Université Paris Cité, CNRS UMR 3571, Synapse and Circuit Dynamics Laboratory, Paris, France.
Francisco J Urra QuirozInstitut Pasteur, Université Paris Cité, CNRS UMR 3571, Synapse and Circuit Dynamics Laboratory, Paris, France.
B Semihcan SermetInstitut Pasteur, Université Paris Cité, CNRS UMR 3571, Synapse and Circuit Dynamics Laboratory, Paris, France.
Nelson RebolaInstitut Pasteur, Université Paris Cité, CNRS UMR 3571, Synapse and Circuit Dynamics Laboratory, Paris, France.
Sanjeev JanarthananDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado USA 80045.
Laura A LynchNeuroscience Institute, 40 Woodlands Way, Princeton University, Princeton, New Jersey USA 08540.
David M TurnerNeuroscience Institute, 40 Woodlands Way, Princeton University, Princeton, New Jersey USA 08540.
David A DiGregorioInstitut Pasteur, Université Paris Cité, CNRS UMR 3571, Synapse and Circuit Dynamics Laboratory, Paris, France.ORCID 0000-0002-6417-4566
Samuel S-H WangNeuroscience Institute, 40 Woodlands Way, Princeton University, Princeton, New Jersey USA 08540.

Funding

Subcortical Neural Coding and DynamicsU19NS104648 · NINDS · PRINCETON UNIVERSITY · PI BRODY, CARLOS D, GOLDMAN, MARK S · 2017 to 2021
$15.3M
Imaging adaptive cerebellar processing at cellular resolution in awake miceR01NS045193 · NINDS · PRINCETON UNIVERSITY · PI WANG, SAMUEL SHENG-HUNG · 2003 to 2024
$7.5M
Use of Calcium Indicator Proteins in Spike Counting ModeR21EY026434 · NEI · PRINCETON UNIVERSITY · PI DIGREGORIO, DAVID A, WANG, SAMUEL SHENG-HUNG · 2015 to 2016
$476k
NEI NIH HHS R21 EY026434NINDS NIH HHS R01 NS045193NINDS NIH HHS U19 NS104648
6 · The paper itself

Abstract

The intramolecular dynamics of fluorescent calcium indicators distort the relationship between calcium signals and action potentials ("spikes"), hampering efficient spike inference from calcium imaging. To address this problem, we characterized the calcium response kinetics of three widely used indicators, GCaMP6f, jGCaMP7f, and jGCaMP8f, using

Identifiers

PMID42282678
PMCPMC13252099

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.