Evidence map›Paper›PMID 42282676›Full record

ArticlebioRxiv : the preprint server for biology2026

Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology.

Chenyang Li, Dominique Leitner, Zifei Liang, Veronika Yakovishina, Merna Ibrahim, Arline Faustin, Thomas Wisniewski, Youssef Zaim Wadghiri, Yulin Ge, Jiangyang Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenyang LiBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0003-4244-8615
Dominique LeitnerDepartment of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
Zifei LiangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Veronika YakovishinaBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Merna IbrahimBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Arline FaustinDepartment of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
Thomas WisniewskiDepartment of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
Youssef Zaim WadghiriBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Yulin GeBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Jiangyang ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Daniel K Sodickson · 2014 to 2026
$19.3M
Alzheimer’s Disease Related Biomarkers following SARS-CoV-2 InfectionR01AG077422 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jennifer Ann Frontera, Yulin Ge · 2022 to 2026
$6.9M
Imaging Neonatal Hypoxic Ischemic InjuryR01HD074593 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FRANCES J NORTHINGTON, JIANGYANG ZHANG · 2013 to 2026
$6.8M
Multi-scale and multi-modality imaging of neuropathology in VCIDU24NS135568 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JAMES C GEE, Yulin Ge · 2023 to 2026
$6.6M
In vivo insights of small vessel changes with age using USPIO-enhanced MRIR01NS108491 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN, HAACKE, EWART MARK · 2018 to 2022
$3.7M
ARIA Pathophysiology Characterized by in vivo Neuroimaging, Plasma Biomarkers and Post-Mortem ProteomicsU24NS141774 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN, LU, HANZHANG · 2025 to 2025
$3.3M
7T Small Animal MRI Scanner Replacement for Translational Imaging ResourceS10OD018337 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOADA, FERNANDO E · 2014 to 2014
$2.0M
The 10th International Society for Neurovascular Disease (ISNVD) Annual MeetingR13AG067684 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GE, YULIN · 2020 to 2020
$50k
NCI NIH HHS P30 CA016087NIA NIH HHS P30 AG066512NIA NIH HHS R01 AG077422NIA NIH HHS R13 AG067684NIBIB NIH HHS P41 EB017183NICHD NIH HHS R01 HD074593NIH HHS S10 OD018337NINDS NIH HHS R01 NS108491NINDS NIH HHS U24 NS135568NINDS NIH HHS U24 NS141774
6 · The paper itself

Abstract

Purpose: To investigate the short-T1 fraction as a potential biomarker of white matter myelin integrity, using myelin histology as ground truth. Methods: Multi-inversion-time MRI data were acquired from four postmortem brain hemisphere specimens from donors with Alzheimer's disease on a clinical 3T scanner, and from five dissected tissue blocks containing white matter hyperintensities (WMHs) on a preclinical 3T system. Short-T1 fraction maps were generated using inverse Laplace transform to isolate short-T1 components and were compared with T2-based myelin water imaging metrics through joint T1-T2 correlation analysis. Short-T1 fraction maps from the tissue blocks were further compared with myelin-stained histology. In addition, Results: Postmortem MRI revealed reduced short-T1 fractions in WMHs. T1-T2 correlation analysis showed that the short-T1 fraction was closely associated with the short-T2 (myelin water) component. Strong correlations were observed between short-T1 fractions and optical densities from both Luxol Fast Blue- and myelin basic protein-stained histological sections, supporting the link between the short-T1 signal and myelin content. Consistent findings were also observed Conclusion: The short-T1 fraction correlated with myelin content in postmortem brain white matter, supporting its potential as a clinically translatable biomarker of myelin integrity.

Indexed as

magnetic resonance imagingmyelinpostmortemshort T1T2white-matter hyper-intensity

Identifiers

PMID42282676
PMCPMC13252140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.