Evidence map›Paper›PMID 42282662›Full record

ArticlebioRxiv : the preprint server for biology2026

Multi-Omics Characterization of Human Molecular Responses to Spaceflight Across Two Independent Missions.

Abirami Santhanam, Zeineen Momin, Xiang Qin, Qiaoyan Wang, Aparna Krishnavajhala, Qi Jiang, Kimberly Walker, Divya Kalra, Marie-Claude Gingras, Hsu Chao and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Abirami SanthanamHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Zeineen MominHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Xiang QinHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Qiaoyan WangHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Aparna KrishnavajhalaHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Qi JiangHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Kimberly WalkerHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Divya KalraHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Marie-Claude GingrasHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Hsu ChaoHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Kavya KottapalliHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Sravya V BhamidipatiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Mishfak A M MansoorBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Sarah A AshiquealiRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
S Michelle GriffinAxiom Space, Houston, TX, USA; Present Address: Center for Translational Injury Research (CeTIR), Department of Surgery, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Michal M MasternakBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Jimmy WuCenter for Space Medicine, Baylor College of Medicine, Baylor College of Medicine Houston, TX, USA.
Donna MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Emmanuel UrquietaCenter for Space Medicine, Baylor College of Medicine, Baylor College of Medicine Houston, TX, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Harsha DoddapaneniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
NCI NIH HHS P30 CA125123
6 · The paper itself

Abstract

Human spaceflight has historically been led by government agencies, but the emergence of commercial organizations is enabling broader participation and new research opportunities. In this study, we present a comprehensive molecular characterization of early human responses to spaceflight, leveraging multi-omics data across the first three weeks of two commercial missions. Biospecimens from six individuals, four from the Axiom 2 mission (10 days) and two from Axiom 3 (21 days), were analyzed using single-cell and bulk RNA sequencing, alongside proteomic profiling. Individual and integrative analyses of these datasets reveal systemic changes in cell types, transcripts, and proteins related to immune regulation, osteoclast differentiation, NF-κB signaling, and blood homeostasis pathways. Importantly, several of the detected pathways align with physiological patterns observed in longer-duration missions. This work establishes a foundational resource for understanding early adaptation to spaceflight at the cellular and molecular levels, providing insights to reduce future space-travel health risks.

Indexed as

Axiom missions (Ax-2, Ax-3)Bulk RNA sequencingCoagulation pathwaysMulti-omicsNF-κB signalingOsteoclast differentiationPlatelet activationProteomicsSingle-cell RNA-seqSpaceflight

Identifiers

PMID42282662
PMCPMC13252042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.