Evidence map›Paper›PMID 42282661›Full record

ArticlebioRxiv : the preprint server for biology2026

General prediction of T cell receptor antigen specificity from sequence using AlphaFold 3.

Lawson J Woods, Brandon Neff, Kamel Lahouel, Antoine Goursaud, Mete Mulazimoglu, Kameron Bates, Cristian Tomasetti, John A Altin

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lawson J WoodsThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Brandon NeffThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Kamel LahouelThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Antoine GoursaudThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Mete MulazimogluThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Kameron BatesThe Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Cristian TomasettiCity of Hope Comprehensive Cancer Center, Duarte, California, United States.
John A AltinThe Translational Genomics Research Institute (TGen), Flagstaff, AZ, USA.

Funding

Functionally distinct human CD4 T cell responses to novel evolutionarily selected M. tuberculosis antigensR01AI173002 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joel D. Ernst · 2023 to 2026
$3.4M
MYCOBACTERIUM TUBERCULOSIS PROTEOME-WIDE EPITOPE DISCOVERY AND HOST TRANSCRIPTOME-WIDE T CELL PHENOTYPING IN HIGH DISEASE BURDEN POPULATIONS75N93024C00054 · NIAID · TRANSLATIONAL GENOMICS RESEARCH INST · PI ALTIN, JOHN · 2024 to 2025
$2.5M
A novel approach for deep phenotyping the CD4 T cell response to Mycobacterium TuberculosisR21AI149311 · NIAID · TRANSLATIONAL GENOMICS RESEARCH INST · PI ALTIN, JOHN, ERNST, JOEL D. · 2020 to 2021
$535k
NIAID NIH HHS R01 AI173002NIAID NIH HHS R21 AI149311NIH HHS 75N93024C00054
6 · The paper itself

Abstract

The Major Histocompatibility Complex (MHC):peptide:T Cell Receptor (TCR) complex is the most diverse trimolecular interface known in nature and a key trigger for adaptive immunity. TCRs are now routinely sequenced at scale, however decoding their specificity for antigens remains a bottleneck. While

Identifiers

PMID42282661
PMCPMC13252052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.