Evidence map›Paper›PMID 42282653›Full record

ArticlebioRxiv : the preprint server for biology2026

The regulatory logic of a dose-dependent developmental fate decision.

Alison H Araten, Emily K Ho, Jared E Toettcher

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Alison H AratenDepartment of Molecular Biology, Princeton University, Princeton, NJ, US.
Emily K HoDepartment of Molecular Biology, Princeton University, Princeton, NJ, US.ORCID 0000-0002-2303-2801
Jared E ToettcherDepartment of Molecular Biology, Princeton University, Princeton, NJ, US.ORCID 0000-0002-1546-4030

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Control of the 4D chromatin landscape underlying gene activity during developmentU01DK127429 · NIDDK · PRINCETON UNIVERSITY · PI GREGOR, THOMAS, LEVINE, MICHAEL STEVEN · 2020 to 2024
$3.2M
A new class of biosensors for detecting signaling dynamics without live-cell microscopyR01GM144362 · NIGMS · PRINCETON UNIVERSITY · PI TOETTCHER, JARED E · 2022 to 2025
$1.3M
Optogenetics and biosensors for dissecting cellular decision-makingR35GM164185 · NIGMS · PRINCETON UNIVERSITY · PI Jared E Toettcher · 2026 to 2026
$369k
Optogenetic dissection of Erk signal interpretation in early embryogenesisF32GM148016 · NIGMS · PRINCETON UNIVERSITY · PI HO, EMILY KOLENBRANDER · 2023 to 2024
$146k
NIDDK NIH HHS U01 DK127429NIGMS NIH HHS F32 GM148016NIGMS NIH HHS R01 GM144362NIGMS NIH HHS R35 GM164185NIH HHS P40 OD018537
6 · The paper itself

Abstract

In canonical developmental patterning, the embryo is exposed to gradients of signaling activators that elicit different cellular responses depending on the activator's concentration. Recent optogenetic studies of terminal ERK signaling downstream of Torso receptor tyrosine kinase in the early

Identifiers

PMID42282653
PMCPMC13252119

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.