ArticlebioRxiv : the preprint server for biology2026
A Viral Mutation Profiling and Discovery Strategy for Sensitive Multiplex Detection of Viruses and Variants in Saliva by Proteomics.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background: Detecting multiple viruses in biofluids such as saliva remains challenging because of rapid mutation and low abundance presenting in the complex matrix. Proteomics analysis provides a complementary method by directly measuring viral peptides and resolving protein-level sequence variation in rapidly evolving viruses such as influenza and SARS-CoV-2. However, the ongoing viral evolution challenges search sensitivity by introducing numerous mutations. Here, we develop a saliva viral proteomics strategy that integrates mutation profiling of clinically relevant viral sequences with single amino acid substitution mutation discovery to enable sensitive detection of both known and emerging variants. Results: Conclusions: This study provides a scalable framework for mutation profiling and discovery proteomics analysis that enables sensitive detection of both known and emerging viral variants in complex clinical samples.
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