ArticlebioRxiv : the preprint server for biology2026
Modulation of Ferroptosis During Early
Joshua J Ivie, Sylvia Stull, Ethan Bustad, Courtney R Plumlee, Sara B Cohen, Fergal J Duffy, Alan H Diercks, John D Aitchison, Kevin B Urdahl, Alexis Kaushansky and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Sylvia StullCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Ethan BustadCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Courtney R PlumleeCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Sara B CohenCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Fergal J DuffyCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Alan H DiercksCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
John D AitchisonCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Kevin B UrdahlCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Alexis KaushanskyCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Alissa C RothchildDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst.ORCID 0000-0001-7484-1193 Benjamin H GernCenter for Global Infectious Disease Research, Seattle Children's Research Institute.ORCID 0000-0002-0142-5970 Shuyi MaCenter for Global Infectious Disease Research, Seattle Children's Research Institute.
Funding
IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6MSystems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ALLAND, DAVID, ELLNER, JERROLD J. · 2021 to 2025
$13.9MACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7MSeattle Tuberculosis Research Advancement CenterP30AI168034 · NIAID · UNIVERSITY OF WASHINGTON · PI Rhea N Coler, CHETAN SESHADRI · 2022 to 2026
$6.3MNetwork Dissection of Host-Pathogen Interactions in Mycobacterium tuberculosis InfectionDP2AI164249 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI MA, SHUYI · 2021 to 2025
$2.8MDissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granulomaK08AI166072 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Benjamin Henry Gern · 2022 to 2026
$929kNIAID NIH HHS DP2 AI164249NIAID NIH HHS K08 AI166072NIAID NIH HHS P30 AI168034NIAID NIH HHS U19 AI162598NICHD NIH HHS T32 HD007233NIH HHS 75N93019C00070
6 · The paper itselfAbstract
Although spread of internalized Mtb from the initial infected alveolar macrophages (AMs) is a crucial determinant of infection outcomes, the role of cell death in facilitating this spread, and how it is regulated by Mtb remains poorly understood. Ferroptosis, a lipid peroxidation-mediated form of necrotic cell death, contributes to pathology during later stages of infection. However, the role of ferroptosis in early AM cell death remains inadequately defined, and its induction during infection has been primarily studied with the laboratory strain, H37Rv. Using gene set variation analysis of single cell RNAseq data profiling Mtb-infected murine lungs, we found that the hypervirulent Beijing sublineage clinical strain SA161 is associated with an elevated pro-ferroptotic transcriptional response in AMs compared to H37Rv by 17 days post infection. Consistent with these transcriptional profiles, we found that SA161 induced increased lipid peroxidation in comparison to H37Rv during infection
Identifiers
PMID42282648
PMCPMC13252049
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