Evidence map›Paper›PMID 42282644›Full record

ArticlebioRxiv : the preprint server for biology2026

Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.

Emmanuel C Ogbonna, Soheil R Talemi, Zoltan Maliga, Ziyuan Zhao, Clarence Yapp, Shishir M Pant, Yi Daniel Lu, Jeremy Muhlich, Andréanne Gagné, Amanda J Martinot and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Emmanuel C OgbonnaLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7378-7957
Soheil R TalemiLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9999-2403
Zoltan MaligaLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4209-7253
Ziyuan ZhaoLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0003-2019-1406
Clarence YappLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1144-5710
Shishir M PantLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-2686-7898
Yi Daniel LuLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0003-1740-161X
Jeremy MuhlichLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0811-637X
Andréanne GagnéLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3833-4159
Amanda J MartinotCummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0001-6237-6191
Shannon CoyLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0033-9031
Sandro SantagataLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7528-9668
Angela R ShihDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-8945-5997
Isaac H SolomonDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0003-3432-0902
Threnesan NaidooAfrica Health Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa.ORCID 0000-0002-1864-4301
Bree B AldridgeLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2236-1424
Adrie J C SteynAfrica Health Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa.ORCID 0000-0001-9177-8827
Peter K SorgerLaboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3364-1838

Funding

A Global Research Resource for Human TuberculosisR24AI186591 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ADRIE JC STEYN · 2024 to 2026
$3.5M
Myeloid-Derived Suppressor Cells in Tuberculosis Granuloma Structure and FunctionR21AI155003 · NIAID · TUFTS UNIVERSITY BOSTON · PI MARTINOT, AMANDA · 2020 to 2021
$474k
Bill & Melinda Gates Foundation INV-027106NIAID NIH HHS R21 AI155003NIAID NIH HHS R24 AI186591Wellcome Trust
6 · The paper itself

Abstract

Tertiary lymphoid structures (TLSs) are sites of immune organization in peripheral tissues that arise from chronic inflammation. They play important roles in infection control and cancer but the mechanisms controlling their formation remain only partly understood. Here, we combine high-plex imaging, serial-section 3D reconstruction, and optimal transport trajectory modeling to reconstruct TLSs in human lungs infected with

Identifiers

PMID42282644
PMCPMC13252128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.