Evidence map›Paper›PMID 42282619›Full record

ArticlebioRxiv : the preprint server for biology2026

CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.

Xu Huang, Hongyi Chen, Larry Reser, Andres V Reyes, Shou-Ling Xu, Jeffrey Shabanowitz, Donald F Hunt, Tai-Ping Sun

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xu HuangDepartment of Biology, Duke University, Durham, North Carolina 27708, USA.
Hongyi ChenDepartment of Biology, Duke University, Durham, North Carolina 27708, USA.
Larry ReserDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Andres V ReyesDepartment of Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, California 94305, USA.
Shou-Ling XuDepartment of Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, California 94305, USA.
Jeffrey ShabanowitzDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Donald F HuntDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA.
Tai-Ping SunDepartment of Biology, Duke University, Durham, North Carolina 27708, USA.ORCID 0000-0001-5223-2936

Funding

PROTEIN SEQUENCING BY TANDEM MASS SPECTROMETRYR01GM037537 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HUNT, DONALD F · 1987 to 2023
$17.8M
Structure and Function Analyses of DELLA Interacting Proteins in ArabidopsisR01GM100051 · NIGMS · DUKE UNIVERSITY · PI SUN, TAI-PING · 2012 to 2021
$2.4M
Structural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in PlantsR01GM150029 · NIGMS · DUKE UNIVERSITY · PI Tai-Ping Sun, Pei Zhou · 2023 to 2026
$1.9M
Thermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600k
NIGMS NIH HHS R01 GM037537NIGMS NIH HHS R01 GM100051NIGMS NIH HHS R01 GM150029NIH HHS S10 OD030441
6 · The paper itself

Abstract

Gibberellin (GA) promotes plant growth primarily by triggering degradation of DELLA transcription regulators, yet how DELLA activity is fine-tuned dynamically by phosphorylation independently of proteolysis remains poorly understood. Here we show that the CDK8 kinase module of the Mediator complex attenuates activity of the

Indexed as

CDK8DELLA-MED15 interactiongibberellin signalingphosphorylation of DELLA proteins

Identifiers

PMID42282619
PMCPMC13252033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.