ArticlebioRxiv : the preprint server for biology2026
Neural synchrony between prefrontal and visual cortex supports visual working memory.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Working memory appears to depend on neural mechanisms that are distributed across the brain. Specifically, neural activity persists in the prefrontal cortex while memories are maintained, and at the same time, the visual contents of memory can be precisely decoded from the patterns of activity in visual cortex. Contemporary models attempt to account for these findings by positing that higher-order areas, like prefrontal cortex, somehow control memory storage by recruiting encoding mechanisms in sensory cortices. Demonstrating how prefrontal cortex influences working memory representations in visual cortex is methodologically challenging and direct evidence remains scarce. Here, we leveraged the excellent temporal resolution of magnetoencephalography to test hypotheses about how synchronization of neural activity between prefrontal and visual cortex coordinates working memory representations. During a visuospatial working memory task in humans (both sexes), increased power in
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