Evidence map›Paper›PMID 42282611›Full record

ArticlebioRxiv : the preprint server for biology2026

Spontaneous and stimulus-driven arousal produce distinct acetylcholine dynamics across sensory and prefrontal cortex.

Anna R Chambers, Eyal Y Kimchi, Yurika Watanabe, Tatenda Chakoma, Daniel B Polley

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna R ChambersEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston MA 02114.
Eyal Y KimchiEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston MA 02114.
Yurika WatanabeEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston MA 02114.ORCID 0000-0001-5031-9018
Tatenda ChakomaEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston MA 02114.
Daniel B PolleyEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston MA 02114.

Funding

Corticofugal Circuits for Active ListeningR01DC017078 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Daniel B. Polley · 2018 to 2026
$5.6M
Determining optimal parameters for dynamic cholinergic modulation of associative learningK08MH116135 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KIMCHI, EYAL YAACOV · 2018 to 2021
$783k
NIDCD NIH HHS R01 DC017078NIMH NIH HHS K08 MH116135
6 · The paper itself

Abstract

Acetylcholine (ACh) release from the basal forebrain has traditionally been viewed as a slow, spatially diffuse signal regulating cortical arousal across sleep and wakefulness

Identifiers

PMID42282611
PMCPMC13251989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.