Evidence map›Paper›PMID 42282601›Full record

ArticlebioRxiv : the preprint server for biology2026

Engineering a Novel Bacterial Encapsulin for Programmable Surface Functionalization: From Single-Target to Mosaic Nanovaccines.

India Boyton, Claire Rennie, Julia van der Hoven, Manuel Del Valle, Dennis Diaz, Juanfang Ruan, Daniel Luque, Bernadette Saunders, Lyndsey E Collins-Praino, Lars Ittner and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

India BoytonAustralian Institute for Microbiology and Infection, University of Technology Sydney, Gadigal Country, Sydney, NSW 2007, Australia.ORCID 0000-0002-1442-1696
Claire RennieSchool of Life Sciences, University of Technology Sydney, Gadigal Country, Sydney, NSW 2007, Australia.ORCID 0000-0003-4533-6627
Julia van der HovenDementia Research Centre, Macquarie University, NSW 2109, Australia.ORCID 0000-0002-9862-3016
Manuel Del ValleViral Vector Manufacturing Facility, Kids Research, The Children's Hospital at Westmead, Level 4/178 Hawkesbury Rd, Westmead, NSW 2145, Australia.
Dennis DiazAll G Co Holdings Pty Limited, NSW 2017, Australia.
Juanfang RuanElectron Microscope Unit, Mark Wainwright Analytical Centre, University of New South Wales Sydney, NSW 2052, Australia.ORCID 0000-0001-8994-5235
Daniel LuqueElectron Microscope Unit, Mark Wainwright Analytical Centre, University of New South Wales Sydney, NSW 2052, Australia.ORCID 0000-0002-0151-6020
Bernadette SaundersSchool of Life Sciences, University of Technology Sydney, Gadigal Country, Sydney, NSW 2007, Australia.ORCID 0000-0003-0540-4445
Lyndsey E Collins-PrainoSchool of Pharmacy and Biomedical Science, Adelaide University, Adelaide, SA 5005, Australia.ORCID 0000-0002-4380-7600
Lars IttnerDementia Research Centre, Macquarie University, NSW 2109, Australia.ORCID 0000-0001-6738-3825
Andrew CareSchool of Life Sciences, University of Technology Sydney, Gadigal Country, Sydney, NSW 2007, Australia.ORCID 0000-0002-0035-7961

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Encapsulins are prokaryotic self-assembling protein nanocages with promise as nanovaccine scaffolds. Their utility as modular platforms require tolerance to surface engineering, high-yield soluble production, formulation stability, and controlled antigen (co-)display. Herein, a previously uncharacterized encapsulin from Alkaliphilus metalliredigens is engineered into a SpyCatcher-decorated nanoscaffold (Am-S) that enables controlled surface display of SpyTagged antigens. Cryo-EM confirms that the native encapsulin forms a

Indexed as

Alzheimer’s Diseaseamyloid betaencapsulinhyperphosphorylated taunanovaccineprotein nanocageSpyCatcher/SpyTag

Identifiers

PMID42282601
PMCPMC13251955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.