ArticlebioRxiv : the preprint server for biology2026
TBC1D23-AAVR Interaction Drives Endosome-to-TGN Trafficking Required for rAAV Transduction.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The adeno-associated virus receptor (AAVR; also known as KIAA0319L) is the proteinaceous receptor required for the transduction of multi-serotype adeno-associated viruses (AAVs). While the extracellular polycystic kidney disease (PKD) domains of AAVR directly bind AAV capsids, the function of its C-terminal cytosolic domain (AAVR-C) in governing AAV internalization and intracellular trafficking remains undefined. Using targeted pulldown of AAVR-interacting host proteins with a glutathione S-Transferase (GST)-fused AAVR-C recombinant protein (GST-AAVR-C) as a bait, we identified that TBC1 domain family member 23 (TBC1D23), a specialized intracellular trafficking adaptor and bridging factor, binds AAVR via the AAVR-C and mediates AAV's endosome-to- Significance: Recombinant adeno-associated viruses (rAAVs) are widely used gene delivery vectors, yet the intracellular trafficking steps that enable productive transduction remain incompletely defined. We identify TBC1D23 as a critical host adaptor that directly binds the cytosolic tail of the AAV receptor (AAVR) and mediates retrograde transport of AAV vectors from endosomes to the
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