Evidence map›Paper›PMID 42282578›Full record

ArticlebioRxiv : the preprint server for biology2026

Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a

Oakleigh M Folkes, Meaghan Donahue, Rafael E Perez, Angélica Minier-Toribio, Paola N Negrón-Moreno, Marina R Picciotto, Yong-Hui Jiang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oakleigh M FolkesDepartments of Genetics, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.ORCID 0000-0001-9664-5783
Meaghan DonahueDepartments of Genetics, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.
Rafael E PerezDepartments of Neuroscience, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.ORCID 0000-0001-7788-4631
Angélica Minier-ToribioDepartments of Neuroscience, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.
Paola N Negrón-MorenoDepartments of Genetics, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.ORCID 0000-0003-4474-6739
Marina R PicciottoDepartments of Neuroscience, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.ORCID 0000-0002-4404-1280
Yong-Hui JiangDepartments of Genetics, University School of Medicine, New Haven, CT, Yale University, New Haven, CT.ORCID 0000-0001-6188-8806

Funding

Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse modelsR01MH117289 · NIMH · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2019 to 2023
$3.2M
Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout MiceR01MH098114 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2012 to 2016
$2.2M
A novel neural circuit analysis paradigm to model autism in miceR21MH104316 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2014 to 2015
$435k
A novel paradigm to dissect the function connectivity in Shank3 autism modelR21HD087795 · NICHD · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2017 to 2018
$434k
Investigations of Neuronal Ensembles and Shank3-Homer Scaffolds on Reward and Social Behavior in a Shank3 model of AutismF32HD106666 · NICHD · YALE UNIVERSITY · PI FOLKES, OAKLEIGH · 2022 to 2024
$224k
NICHD NIH HHS F32 HD106666NICHD NIH HHS R21 HD087795NIMH NIH HHS R01 MH098114NIMH NIH HHS R01 MH117289NIMH NIH HHS R21 MH104316
6 · The paper itself

Abstract

Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode social information will give insight into identifying novel pharmacological targets to address this unmet need.

Identifiers

PMID42282578
PMCPMC13251903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.