Evidence map›Paper›PMID 42282556›Full record

ArticlebioRxiv : the preprint server for biology2026

NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System in

Benson Otarigho, Jonathan Lalsiamthara, Alejandro Aballay

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benson OtarighoDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jonathan LalsiamtharaDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Alejandro AballayDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-5975-3352

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
C. elegans to study organismal control of recovery from bacterial infectionsR01AI117911 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ABALLAY, ALEJANDRO · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI117911NIH HHS P40 OD010440
6 · The paper itself

Abstract

Neural control of innate immunity must balance restraint of basal immune activity with rapid activation upon pathogen encounter. Glutamate, the primary excitatory neurotransmitter in the nervous system, has been implicated in several neurological disorders associated with inflammation, suggesting a potential link to immune regulation. However, how glutamatergic signaling contributes to immune balance remains unknown. Here, we demonstrated that the NMDA-type ionotropic glutamate receptor subunit NMR-2, a component of the NMDA receptor complex, acts in the

Indexed as

GlutamateInnate ImmunityNMR-2Pathogen resistanceSensory neurons

Identifiers

PMID42282556
PMCPMC13252404

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.