Evidence map›Paper›PMID 42282537›Full record

ArticlebioRxiv : the preprint server for biology2026

Hypothalamic MCH neurons links tau pathology to sleep disruption.

Ke Pang, Siyin Guo, Ruilin Yang, Ajay Kumar, Wyatt D Morse, Leann Xu, Qiaoling Liu, Dequan Jiang, Peng Zhong

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ke PangDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Siyin GuoDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Ruilin YangDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Ajay KumarDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Wyatt D MorseDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Leann XuDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Qiaoling LiuDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Dequan JiangDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Peng ZhongDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68106, USA.

Funding

Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Anna Dunaevsky · 2020 to 2026
$20.7M
UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug DiscoveryT32AG076407 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOWARD S FOX, Paul Trippier · 2022 to 2026
$1.1M
NIA NIH HHS T32 AG076407NIGMS NIH HHS P20 GM130447
6 · The paper itself

Abstract

Sleep disruption is an early and pervasive feature of Alzheimer's disease (AD), yet the circuit mechanisms linking tau pathology to sleep-wake dysfunction remain unresolved. Here, we identify melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) as a critical node disrupted in tauopathy. Longitudinal EEG/EMG recordings in

Identifiers

PMID42282537
PMCPMC13251967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.