ArticlebioRxiv : the preprint server for biology2026
CLASH (Chromatin Loop Across-sample Score Harmonizer) quantifies the relative contributions of genetic variation, methylation, and CTCF occupancy on chromatin loop strength across individuals.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Three-dimensional genome organization constrains the regulatory interactions that govern vital cellular processes. Chromatin loops are key features of genome folding, yet it is unclear how genetic and epigenetic variation influences differential loop formation across individuals. Loops primarily form between two CTCF binding proteins, which recognize a specific motif at loop anchors. CTCF binding site motifs are frequently altered by base substitutions, structural variation, and 5-methylcytosine (m
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