ArticleBioinformation2026
Serum 25-hydroxyvitamin D and tear-film stability in dry eye disease: A case-control correlation study.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dry eye disease (DED) involves tear film instability, driving symptoms and epithelial damage, with emerging evidence linking vitamin D deficiency to ocular surface inflammation. Therefore, it is of interest to compare serum 25(OH) D levels and tear parameters in 300 DED eyes (150 patients) versus 270 control eyes (135 matched subjects) at a tertiary center (2022-2024). DED patients showed severe deficiency (mean 13.79±9.36 ng/mL vs 38.13±18.76 ng/mL in controls, p<0.0001), with OSDI 39.85±10.85, TFBUT 6.38±2.75s, ST-I 9.82±5.17 mm, TMH 0.19±1.21 mm, OSS 2.71±0.21; 25(OH)D correlated positively with TMH/ST-I/TFBUT (r=0.775/0.313/0.396) and negatively with OSDI (r=-0.414), all p<0.0001. Vitamin D deficiency is strongly associated with reduced tear volume and stability, as well as worse symptoms, particularly affecting TMH and epithelial integrity. Thus, we show vitamin D as a key modifier of the tear film, supporting its role as an adjuvant therapeutic target alongside standard management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.