ArticleBioinformation2026
Correlation of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with serum-ascites albumin gradient in ascites.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Differentiating portal hypertensive from non-portal hypertensive ascites remains a common clinical challenge, especially in settings where rapid yet cost-effective diagnostic tools are limited. Serum-ascites albumin gradient (SAAG) is the standard method for etiological classification, but simple adjunctive markers may improve early assessment. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inexpensive inflammatory indices with potential diagnostic value. Hence, this cross-sectional study included 100 adult patients with clinically and radiologically confirmed ascites between January and December 2024. Patients were classified into high SAAG (≥1.1 g/dL) and low SAAG (<1.1 g/dL) groups. High SAAG was present in 66% of patients. NLR showed a significant moderate positive correlation with SAAG (r = 0.55; P < 0.001), while PLR showed a weak but significant inverse correlation (r = -0.25; P = 0.0004). NLR >2 demonstrated higher sensitivity (87.9%) and diagnostic accuracy (76.0%), whereas PLR <90 showed higher specificity (64.7%) and positive predictive value (80.3%). ROC analysis showed moderate diagnostic performance for NLR (AUC = 0.72) and PLR (AUC = 0.71). Thus, we show that NLR and PLR may serve as useful non-invasive adjuncts to SAAG for evaluating ascites, particularly in resource-limited settings.
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