ArticleBioinformation2026
Comparative evaluation of nano-hydroxyapatite dentifrice, diode laser alone and combined for dentin hypersensitivity: A randomized clinical trial.
Article in Bioinformation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Dentin hypersensitivity is a common clinical condition characterized by short, sharp pain arising from exposed dentinal tubules, posing a challenge for long-term management. This randomized, single-blind parallel-arm clinical trial evaluated and compared the effectiveness of nano-hydroxyapatite (N-HAP) dentifrice and diode laser used alone and in combination, with fluoride dentifrice as a control. Fifty-five hypersensitive sites were allocated into four groups and sensitivity was assessed using VAS and VDS scores at baseline, immediately post- treatment and at 1, 4 and 8 weeks. All test groups demonstrated a significant reduction in dentin hypersensitivity compared to the control group, with the combination therapy showing the greatest and most sustained reduction. The combined use of N-HAP dentifrice and diode laser exhibits a superior synergistic effect, indicating its potential as an effective approach for managing dentin hypersensitivity.
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