Evidence map›Paper›PMID 42282251›Full record

ArticleMolecular therapy. Nucleic acids2026

Comparative analysis of expression, immunogenicity, and safety profiles between linear and circular RNA vaccine platforms.

Soo-Yeon Lee, Jisun Lee, Jae-Hun Ahn, Seok-Yong Lee, Eun-Jin Choi, Dahyeon Ha, Ayoung Oh, Sohee Jo, Subin Yoon, Seonghyun Lee and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In the age of mRNA vaccines: Linear or circular mRNA?Molecular therapy. Nucleic acids · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soo-Yeon LeeDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Jisun LeeDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Jae-Hun AhnDepartment of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Seok-Yong LeeDepartment of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Eun-Jin ChoiDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Dahyeon HaDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Ayoung OhDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Sohee JoDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Subin YoonDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Seonghyun LeeDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.
Hee-Jin BaeDepartment of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Na-Young LeeDepartment of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Hyewon YounDepartment of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Byeong-Cheol KangDepartment of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Jae-Hwan NamDepartment of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mRNA vaccines have revolutionized development and continue to advance through clinical and research applications. Circular RNA is emerging as a promising alternative to linear RNA. However, no direct comparison has identified the optimal RNA platform for mRNA-based drug development. This study compares linear and circular RNA platforms

Indexed as

circular RNAimmunogenicitylinear RNAmRNA platformMT: Oligonucleotides:therapies and applicationsvaccine

Identifiers

PMID42282251
PMCPMC13251755

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.