Observational studyJournal of medicine and life2026
Effects of vitamin K administration on liver function, inflammation, and coagulation in chronic viral hepatitis: a retrospective study.
Observational study in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin K is essential for coagulation and has increasingly been recognized for its potential role in inflammatory processes. In patients with chronic viral hepatitis, alterations in coagulation parameters and persistent systemic inflammation are frequently observed. This study aimed to evaluate the association between vitamin K administration and changes in liver enzymes, inflammatory markers, and coagulation parameters in patients with chronic viral hepatitis. This retrospective observational study included 94 patients with chronic viral hepatitis hospitalized between January 2020 and December 2024. Laboratory parameters reflecting liver function, inflammatory status, and coagulation profile were assessed at admission and discharge following vitamin K administration. Changes in biological parameters were analyzed using non-parametric tests for paired data. Reductions in liver enzymes, inflammatory markers, and coagulation parameters were observed between admission and discharge. Aspartate aminotransferase and alanine aminotransferase levels decreased, accompanied by lower values of C-reactive protein and erythrocyte sedimentation rate. Coagulation parameters, including prothrombin time and international normalized ratio, also decreased. No significant differences were identified between patients with and without hepatitis B infection. Vitamin K administration in patients with chronic viral hepatitis was associated with changes in liver enzymes, inflammatory markers, and coagulation parameters. These findings suggest a potential role for vitamin K in the interplay between inflammation and hemostasis in chronic liver disease, while its clinical utility should be considered on an individual basis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.