Evidence map›Paper›PMID 42282215›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Longitudinal changes of iron in the substantia nigra of early-stage Parkinson's disease.

Guangwei Du, Christopher Sica, Sol De Jesus, Lan Kong, Richard B Mailman, Xuemei Huang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Guangwei DuDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.ORCID 0000-0002-8267-0301
Christopher SicaDepartment of Radiology, Rush University, Chicago, IL 60612.
Sol De JesusDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.
Lan KongSchool of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, PA 17033.
Richard B MailmanDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-1353-2738
Xuemei HuangDepartment of Neurology, University of Virginia, Charlottesville, VA 22908.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033184 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2011 to 2011
$4.5M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
Structural MRI marker(s) of Parkinson's Disease's ProgressionR01NS060722 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2009 to 2013
$2.9M
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NCRR NIH HHS UL1 RR033184NINDS NIH HHS R01 NS060722NINDS NIH HHS U01 NS082151
6 · The paper itself

Abstract

Background: Higher iron occurs in the substantia nigra in Parkinson's disease (PD), but its behavior over time is poorly understood. Objective: To determine if nigral iron measured by quantitative susceptibility MRI can track progression of early stages of PD. Methods: Thirty-four early-stage PD patients (disease duration < 4 yrs) and 35 matched controls were recruited. Iron content in the substantia nigra and related regions was obtained using quantitative susceptibility mapping with zero-referencing at both baseline and one-year follow-up, along with clinical metrics. Results: Of five clinic metrics and five regional iron measures, only MDS-UPDRS II (p = 0.046) and SNc iron (p = 0.004) showed significant changes for PD subjects in the one-year epoch. The changes of SNc iron also were correlated with changes of MDS-UPDRS II (p = 0.005). Conclusion: Nigral iron content measured by zero-referencing is sensitive for tracking disease progression in early-stage PD.

Indexed as

brain ironlongitudinalParkinson’s diseasesubstantia nigrasusceptibility MRI

Identifiers

PMID42282215
PMCPMC13252487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.