Evidence map›Paper›PMID 42282212›Full record

ArticlemedRxiv : the preprint server for health sciences2026

HFE genotype influences substantia nigra iron accumulation and Parkinson's disease progression.

Guangwei Du, Ernest Wang, Christopher Sica, Rachael Stone, Sol De Jesus, Lan Kong, Richard B Mailman, Xuemei Huang

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangwei DuDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.ORCID 0000-0002-8267-0301
Ernest WangDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.
Christopher SicaDepartment of Radiology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.
Rachael StoneDepartment of Neurology, University of Virginia School of medicine, Charlottesville VA 22903.
Sol De JesusDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.
Lan KongSchool of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, PA 17033.ORCID 0000-0001-6098-9445
Richard B MailmanDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville VA 22903.ORCID 0000-0003-1353-2738
Xuemei HuangDepartment of Neurology, Penn State Milton S. Hershey Medical Center, Hershey PA 17033.ORCID 0000-0003-3583-5502

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033184 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2011 to 2011
$4.5M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
NCATS NIH HHS UL1 TR000127NCRR NIH HHS UL1 RR033184NINDS NIH HHS U01 NS082151
6 · The paper itself

Abstract

Increased iron in the substantia nigra has been thought to be a mechanism potentially related to the etiology and/or progression of Parkinson's disease (PD). We hypothesized that genetic variants of

Indexed as

brain ironHFEParkinson’s diseasesusceptibility MRI

Identifiers

PMID42282212
PMCPMC13252428

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.