Evidence map›Paper›PMID 42282183›Full record

ArticlemedRxiv : the preprint server for health sciences2026

APOE and amyloid-tau pathology in cognitively unimpaired older adults.

Carlos Albarrán Morillo, Lukai Zheng, Elham Ghanbarian, Babak Khorsand, Crystal M Glover, Joshua D Grill, S Ahmad Sajjadi, Alzheimer’s Disease Neuroimaging Initiative, Ali Ezzati

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Carlos Albarrán MorilloDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0002-1173-7329
Lukai ZhengDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0003-1328-2791
Elham GhanbarianDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0009-0009-1733-9928
Babak KhorsandDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0002-1585-3909
Crystal M GloverDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0002-1430-7463
Joshua D GrillAlzheimer's Disease Research Center, Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, CA, USA.ORCID 0000-0002-4215-7589
S Ahmad SajjadiDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0002-8960-2213
Alzheimer’s Disease Neuroimaging Initiative
Ali EzzatiDepartment of Neurology, University of California, Irvine, CA, USA.ORCID 0000-0003-1307-4589

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
SCAN: Standardized Centralized Alzheimer's and Related Dementias NeuroimagingU24AG067418 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI JACK, CLIFFORD R., JAGUST, WILLIAM J. · 2020 to 2025
$9.3M
Validation of the Remote Cognitive Aging and Alzheimer’s Disease REsearch (R-CARE) Toolbox for Diverse PopulationsR01AG080635 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Ali Ezzati, Richard B. LIPTON · 2023 to 2026
$8.6M
Discovery and Trial Ready Cohort for Limbic Predominant Age Related TDP-43 Encephalopathy (TRC LATE)R01AG095017 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ali Ezzati, Crystal M. Glover · 2025 to 2026
$6.3M
Genetic Drivers of Resilience to Alzheimer's DiseaseR01AG059716 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2018 to 2022
$4.4M
Genomic and Metabolomic Data Integration in a Longitudinal Cohort at Risk for Alzheimer's DiseaseR01AG054047 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ENGELMAN, CORINNE D. · 2016 to 2020
$3.6M
NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054047NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG080635NIA NIH HHS R01 AG095017NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG068057NIA NIH HHS U24 AG067418NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855
6 · The paper itself

Abstract

introductionAPOE genotype shows well-established dose-dependent associations with higher amyloid in cognitively unimpaired (CU) adults. In contrast, associations with tau burden and cognition are less well characterized.

methodsWe performed a cross-sectional analysis of harmonized multi-cohort ADSP-PHC data from 4,380 CU participants across 4 cohorts with APOE genotype, amyloid PET, and cognitive data from four domains of memory, language, executive, and visuospatial function, including a subset of 758 with tau PET imaging.

resultsAPOE ε4 showed a strong dose-dependent association with amyloid burden and amyloid positivity, with the highest levels observed among ε4 homozygotes. Associations between APOE and global tau burden were more modest and appeared to be driven mainly by ε4 homozygotes, while regional analyses showed localized APOE ε4-related associations in medial temporal regions. Independently, higher tau burden was associated with lower memory and language performance.

conclusionsIn CU older adults, APOE ε4 was most strongly associated with amyloid burden, with more modest associations observed for medial temporal tau burden.

Indexed as

ADSP-PHCAlzheimer’s diseaseamyloid burdenamyloid PETAPOEbiomarkerscognitive declinetau pathologytau PET

Identifiers

PMID42282183
PMCPMC13252495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.