Evidence map›Paper›PMID 42282182›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Cardiovascular risk and hippocampal-cognitive coupling in Alzheimer's disease.

Sofia Fernandez-Lozano, Sylvia Villeneuve, D Louis Collins

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sofia Fernandez-LozanoMontreal Neurological Institute, McConnell Brain Imaging Centre, Montreal, Quebec, Canada.ORCID 0000-0003-2288-8111
Sylvia VilleneuveMontreal Neurological Institute, McConnell Brain Imaging Centre, Montreal, Quebec, Canada.ORCID 0000-0003-2338-0467
D Louis CollinsMontreal Neurological Institute, McConnell Brain Imaging Centre, Montreal, Quebec, Canada.ORCID 0000-0002-8432-7021

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

introductionThe Framingham Risk Score (FRS) indexes cardiovascular risk (CVR), but age-weighting may confound associations with brain and cognitive outcomes.

methodsIn 923 amyloid-positive ADNI participants, we compared FRS against a Multiple Indicators Multiple Causes (MIMIC)-derived age-adjusted measure (CVR

resultsFRS predicted hippocampal atrophy in all six LGCM models; CVR DISCUSSION: FRS "effects" on hippocampal-cognitive decline largely reflect age-related variance. Age-adjusted measures complement FRS by isolating cardiovascular effects from aging.

Indexed as

age-confoundingAlzheimer’s diseaseCardiovascular riskcognitive declineFramingham Risk ScorehippocampusMIMIC model

Identifiers

PMID42282182
PMCPMC13252440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.