Evidence map›Paper›PMID 42282179›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A genome-wide association study of young onset Parkinson's disease in European ancestry.

Ingeborg Haugesag Lie, Janna van Wetering, Miko Valori, Kajsa Atterling Brolin, Kathryn Step, Claudia Schulte, Hirotaka Iwaki, Sara Bandres-Ciga, Hampton Leonard, Manu Sharma and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ingeborg Haugesag LieDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Janna van WeteringDepartment of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Miko ValoriDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Kajsa Atterling BrolinGlobal Parkinson's Genetics Program (GP2).
Kathryn StepDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID 0000-0002-4054-7030
Claudia SchulteDepartment of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.
Sara Bandres-CigaGlobal Parkinson's Genetics Program (GP2).
Hampton LeonardGlobal Parkinson's Genetics Program (GP2).ORCID 0000-0003-2390-8110
Manu SharmaInstitute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany.
International Parkinson’s Disease Genomics Consortium
Global Parkinson’s Genetics Program
Andrew SingletonGlobal Parkinson's Genetics Program (GP2).
Lasse PihlstrømDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-7635-8645

Funding

GENETIC ANALYSIS OF ONSET AGE OF PARKINSONS DISEASER01NS036960 · NINDS · WADSWORTH CENTER · PI PAYAMI, HAYDEH · 1998 to 2012
$3.9M
NINDS NIH HHS R01 NS036960
6 · The paper itself

Abstract

Young onset Parkinson's disease may be caused by biallelic mutations in

Indexed as

age at onsetgeneticsGWASmitochondrial pathwayParkinson’s disease

Identifiers

PMID42282179
PMCPMC13252445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.