Evidence map›Paper›PMID 42282068›Full record

ArticleEuropean heart journal open2026

Standardized processing of explanted hearts after stereotactic arrhythmia radiotherapy (Bio-STAR): a STOPSTORM framework and first human findings.

Sotirios Nedios, Judith Hüttemeister, Emanuel Heil, Petra Büttner, Kerstin Bode, Nils Henrik Nicolay, Franziska Nägler, Christos Moustakis, Alexey Dashkevich, Michal Nozdrzykowski and 24 more

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In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Sotirios NediosDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-4222-6633
Judith HüttemeisterDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0009-0002-8263-616X
Emanuel HeilDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0001-9782-8311
Petra BüttnerDepartment of Cardiology, Heart Center Leipzig at University of Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-0799-4725
Kerstin BodeDepartment of Electrophysiology, Heart Center Leipzig, University of Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0002-1657-7897
Nils Henrik NicolayDepartment of Radiation Oncology, University Hospital Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0003-2550-1410
Franziska NäglerDepartment of Radiation Oncology, University Hospital Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany.
Christos MoustakisDepartment of Radiation Oncology, University Hospital Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-8879-2350
Alexey DashkevichDepartment of Cardiac Surgery, Leipzig Heart Center, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0001-6166-7210
Michal NozdrzykowskiDepartment of Cardiac Surgery, Leipzig Heart Center, Strümpellstraße 39, 04289 Leipzig, Germany.
Michael BorgerDepartment of Cardiac Surgery, Leipzig Heart Center, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-1046-1364
Martin NeefClinic and Policlinic for Cardiology, University Hospital Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.
Rolf WachterClinic and Policlinic for Cardiology, University Hospital Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-2231-2200
Ulrich LaufsClinic and Policlinic for Cardiology, University Hospital Leipzig, Strümpellstraße 39, 04289 Leipzig, Germany.ORCID https://orcid.org/0000-0003-2620-9323
Tomasz JadczykDepartment of Cardiology and Structural Heart Diseases, Medical University of Silesia, ul. Ziołowa 45-47, 40-635 Katowice, Poland.ORCID https://orcid.org/0000-0002-7955-9100
Bert VandenberkDepartment of Cardiovascular Sciences, University of Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0001-8296-920X
Tevfik IsmailSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Campus, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-1691-7599
Ursula RohrerSchool of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Campus, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.ORCID https://orcid.org/0000-0002-5278-6362
Claudia Herrera SiklódyDepartment of Cardiology, CHUV, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-6881-3073
Moritz SinnerDepartment of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, 81377 Munich, Germany.
Niccolò Giaj LevraDepartment of Advanced Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni, 37024 Negrar di Valpolicella, Italy.
Gaetano Maria De FerrariDivision of Cardiology, Cardiovascular and Thoracic Department, Città Della Salute e Della Scienza Hospital, Corso Bramante 88/90, 10126 Torino, Italy.
Daniel ScherrDepartment of Internal Medicine, Karl-Franzens-University Hospital, Auenbruggerplatz 15, 8036 Graz, Austria.ORCID https://orcid.org/0000-0001-5868-5493
Adrian ZamanDepartment of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Boldizsar KovacsDepartment of Cardiology, Universitätsspital Zürich, University Hospital Zürich, Rämistrasse 100, 8091 Zurich, Switzerland.
Stephan HohmannSt.Bernhard Krankenhaus, Hildesheim, Treibestraße 9, 31134  Germany.ORCID https://orcid.org/0000-0002-1606-3423
Nicolaus AndratschkeDepartment of Radiation Oncology, University Hospital of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3647-5916
Franziska HausmannCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0002-2432-7716
Felix MehrhofCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0003-0553-4290
Etienne PruvotHeart and Vessel Department, Service of Cardiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-1386-9285
Katja ZeppenfeldCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0002-7034-1017
Oliver BlanckDepartment of Radiation Oncology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.ORCID https://orcid.org/0000-0003-1391-1308
Gerhard HindricksDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0002-0132-0773
Felix HohendannerDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Charitéplatz 1, 10117 Berlin, Germany.ORCID https://orcid.org/0000-0002-0194-4615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Stereotactic arrhythmia radiotherapy (STAR) is an emerging non-invasive option for refractory ventricular tachycardia (VT); yet, the underlying myocardial effects in humans remain poorly understood. Within the STOPSTORM consortium, we developed the Bio-STAR framework for standardized Methods and results: Bio-STAR standardizes myocardial sampling into non-irradiated control (NFNI), minimally fibrotic irradiated, and fibrotic irradiated zones, guided by visual inspection, electroanatomical maps, and radiotherapy dose overlays. Recommended analyses span Conclusion: Bio-STAR provides a reproducible framework for multimodal analysis of STAR-treated myocardium, enabling harmonized cross-centre research. Early human data demonstrate that cardiomyocyte viability and isolatability are preserved across all assessed regions and that STAR-exposed areas may exhibit region-specific structural features, while functional data on Ca

Indexed as

Calcium handlingExplanted human heartMyocardial remodellingStereotactic arrhythmia radiotherapySTOPSTORMVentricular tachycardia

Identifiers

PMID42282068
PMCPMC13252480

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