ArticleResearch square2026
Chromatin architecture sets origin licensing capacity.
Eric J Foss, Ilana M Nodelman, Alexa Usenko, Holden Furutani, Ayush Goel, Brandon Lofts, Shawna Miles, Zhiguo Zhang, Gregory D Bowman, Toshio Tsukiyama and 1 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Eric J FossDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Alexa UsenkoDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Holden FurutaniDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Ayush GoelDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Brandon LoftsDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Shawna MilesDivision of Translational Sciences and Therapeutics and Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Zhiguo ZhangInstitute for Cancer Genetics, Department of Pediatrics and Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, 10032, USA.ORCID https://orcid.org/0000-0002-9451-2685 Toshio TsukiyamaDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Funding
Structural and Functional Characterization of the Chd1 Chromatin RemodelerR01GM084192 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BOWMAN, GREGORY DEAN · 2008 to 2024
$6.3MMolecular mechanisms and functions of global chromatin controlR35GM139429 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TOSHIO TSUKIYAMA · 2021 to 2026
$4.6MOrigin firing at repetitive sequences and genome replication - Admin SupplementR01GM117446 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDALOV, ANTONIO · 2016 to 2023
$4.3MNIGMS NIH HHS R01 GM084192NIGMS NIH HHS R01 GM117446NIGMS NIH HHS R35 GM139429
6 · The paper itselfAbstract
Replication origin licensing enables complete and faithful genome duplication, yet how chromatin regulates this process
Identifiers
PMID42282035
PMCPMC13252518
What OpenQuestion holds
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LicenceCC BY
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