Evidence map›Paper›PMID 42282028›Full record

ArticleResearch square2026

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.

Gaudenz Danuser, Gabriel Gihana, Kushal Bhatt, Bo-Jui Chang, Vasanth Siruvallur Murali, Felix Zhou, Jungsik Noh, Roshan Ravishankar, Hazel Borges, Jinlong Lin and 8 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gaudenz DanuserUT Southwestern Medical Center.
Gabriel GihanaUniversity of Texas Southwestern Medical Center.ORCID 0000-0002-5443-4440
Kushal BhattUT Southwestern Medical Center.
Bo-Jui ChangUT Southwestern Medical Center.ORCID 0000-0002-5513-7106
Vasanth Siruvallur MuraliThe University of Texas Southwestern Medical Center.ORCID 0000-0002-1782-7034
Felix ZhouUT Southwestern Medical Center.ORCID 0000-0003-4463-1165
Jungsik NohUniversity of Texas Southwestern Medical Center.ORCID 0000-0003-1823-8589
Roshan RavishankarUniversity of Texas Southwestern Medical Center.
Hazel BorgesUT Southwestern Medical Center.
Jinlong LinJohns Hopkins University.
Jessica OcegueraUniversity of Texas Southwestern Medical Center.
Pedro Augusto Silva NogueiraUT Southwestern Medical Center.
Lizbeth Perez-CastroUT Southwestern Medical Center.ORCID 0000-0001-7281-2233
Niranjan VenkateswaranUT Southwestern Medical Center.
Bingying ChenUniversity of Texas Southwestern Medical Center.
Reto FiolkaUT Southwestern.ORCID 0000-0002-4636-5000
Maralice Conacci-SorrellUT Southwestern Medical Center.ORCID 0000-0002-4371-5087
Kevin DeanUT Southwestern Medical Center.ORCID 0000-0003-0839-2320

Funding

Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ LevelU54CA268072 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kevin Michael Dean · 2021 to 2026
$9.1M
UTSW-UNC Center for Cell Signaling AnalysisRM1GM145399 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Kevin Michael Dean, Klaus M. Hahn · 2022 to 2026
$6.2M
Transformative microscopes to image across spatiotemporal scalesR35GM133522 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Reto Paul Fiolka · 2019 to 2026
$3.1M
Integrated visualization, control, and analysis of GEF – GTPase networks in living cellsR01CA252826 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DEAN, KEVIN MICHAEL, HAHN, KLAUS M. · 2021 to 2025
$2.6M
The kynurenine-AHR pathway in biomass production - Revision - 2R01CA245548 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CONACCI-SORRELL, MARALICE · 2020 to 2024
$2.2M
Uncovering novel players in nucleolar organization and function - Equipment SupplementR01GM145744 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CONACCI-SORRELL, MARALICE · 2022 to 2025
$1.6M
NCI NIH HHS R01 CA245548NCI NIH HHS R01 CA252826NCI NIH HHS U54 CA268072NIGMS NIH HHS R01 GM145744NIGMS NIH HHS R35 GM133522NIGMS NIH HHS RM1 GM145399
6 · The paper itself

Abstract

For over three decades, we have known that oncogenic RAS alters the actin cytoskeleton organization and cell surface morphology

Identifiers

PMID42282028
PMCPMC13252579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.