Evidence map›Paper›PMID 42282027›Full record

ArticleResearch square2026

Ontology-constrained multi-LLM scoring of hypothesis support in the predictive processing literature.

Hamed Nejat, Alexander Maier, Jesse Spencer-Smith, André M Bastos

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamed NejatDepartment of Psychology and Vanderbilt Brain Institute, Vanderbilt University.
Alexander MaierDepartment of Psychology and Vanderbilt Brain Institute, Vanderbilt University.
Jesse Spencer-SmithData Science Institute, Vanderbilt University.
André M BastosDepartment of Psychology and Vanderbilt Brain Institute, Vanderbilt University.

Funding

Testing the Mechanisms, Layers, and Frequencies of Prediction Encoding and its ViolationR00MH116100 · NIMH · VANDERBILT UNIVERSITY · PI BASTOS, ANDRE MORAES · 2021 to 2023
$729k
NIMH NIH HHS R00 MH116100
6 · The paper itself

Abstract

Fragmentation is common in interdisciplinary fields with diverse methods and theoretical commitments. Predictive coding neuroscience is a clear example: its literature spans computational theory, electrophysiology, imaging, behavior, and modeling, creating a synthesis problem that conventional meta-analysis cannot easily resolve. Here, we describe a local multi-LLM pipeline for ontology-constrained literature synthesis. The pipeline reads papers, extracts evidence, incorporates figure descriptions, assembles constrained prompts, and validates outputs against an expert glossary. We defined a predictive-coding glossary of thirty-six concepts grouped into three hypotheses: predictive suppression, feedforward error propagation, and ubiquity. A council of ten local language models scored 31 studies across local and global oddball contexts. This enabled pairwise study-agreement analysis, cross-model comparison, and three-dimensional hypothesis-space mapping. Agreement was stronger for local than global oddball contexts, particularly for feedforward error propagation. Hypothesis-space temperature was lower for local oddball contexts and higher for global oddball contexts, indicating greater dispersion in the latter. These results show that local multi-LLM councils can produce auditable disagreement measurements that map heterogeneous literatures into quantitative evidence spaces.

Indexed as

computational neurosciencehypothesis mappinglarge language modelsliterature synthesisontologypredictive coding

Identifiers

PMID42282027
PMCPMC13252565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.