ArticleResearch square2026
Short-term HPV detection dynamics across hormonal contraceptive methods in adolescent girls and young women: a secondary analysis of a randomized trial in South Africa.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
Funding
Abstract
Background: Human papillomavirus (HPV) is highly prevalent in adolescent girls and young women (AGYW) in sub-Saharan Africa. We evaluated short-term differences in HPV prevalence and early detection dynamics across hormonal contraceptive methods in AGYW. Methods: Ninety-eight AGYW (15-19 years) were randomized to receive norethisterone enanthate (Net-EN), combined oral contraceptive pills (COCPs), or a combined contraceptive vaginal ring (CCVR). Cervical samples were collected at baseline and 16-weeks for HPV genotyping. Results: Baseline HPV prevalence was high (93/98; 94.9%) and remained high at 16-weeks (87/97; 89.5%), with no significant differences between contraceptive methods. Longitudinal analyses (n = 87 paired samples) showed no statistically significant differences in HPV acquisition, persistence, or clearance. Conclusions: No significant differences were observed in HPV outcomes between hormonal contraceptive methods over 16-weeks. Findings should be interpreted as exploratory given the small sample size and short follow-up.
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