Evidence map›Paper›PMID 42281971›Full record

ArticleResearch square2026

Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.

Seonggyun Han, Sylvanus Toikumo, Sarah Colbert, Niamh Mullins, Alexander S Hatoum, Emily DiBlasi, Robert Krueger, Rachel Kember, Andrey Shabalin, Henry Kranzler and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Seonggyun HanUniversity of Utah School of Medicine.ORCID 0000-0003-2227-4953
Sylvanus ToikumoUniversity of Pennsylvania.ORCID 0000-0002-6024-0693
Sarah ColbertIcahn School of Medicine at Mount Sinai.ORCID 0000-0003-3060-7471
Niamh MullinsIcahn School of Medicine.ORCID 0000-0001-8021-839X
Alexander S HatoumWashington University Physicians.ORCID 0000-0002-8002-7267
Emily DiBlasiUniversity of Utah School of Medicine.
Robert KruegerUniversity of Minnesota.ORCID 0000-0001-9127-5509
Rachel KemberUniversity of Pennsylvania School of Medicine.ORCID 0000-0001-8820-2659
Andrey ShabalinUniversity of Utah School of Medicine.ORCID 0000-0003-0309-6821
Henry KranzlerUniversity of Pennsylvania Perelman School of Medicine.ORCID 0000-0002-1018-0450

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twinsR01AG053217 · NIA · UNIVERSITY OF MINNESOTA · PI Robert F Krueger, Glenn I Roisman · 2016 to 2026
$9.1M
Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption StudyR01AG077742 · NIA · UNIVERSITY OF MINNESOTA · PI Robert F Krueger, Glenn I Roisman · 2022 to 2026
$3.9M
Genome-Wide Association Analysis of Suicide DeathR01MH123619 · NIMH · UNIVERSITY OF UTAH · PI DOCHERTY, ANNA R. · 2020 to 2024
$3.2M
Genetic risk discovery using WGS from a population-based resource of 10,000 suicide deaths with DNAR01MH122412 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hilary Coon · 2020 to 2026
$2.7M
Harnessing the genetics of chronic pain to inform the development of non-additive analgesic medicationsK99DA060906 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI TOIKUMO, SYLVANUS · 2025 to 2025
$118k
NIA NIH HHS R01 AG053217NIA NIH HHS R01 AG077742NIA NIH HHS U19 AG051426NIDA NIH HHS K99 DA060906NIMH NIH HHS R01 MH122412NIMH NIH HHS R01 MH123619
6 · The paper itself

Abstract

Although chronic pain is a major risk factor for suicidal behaviors, the shared genetic underpinnings of these phenotypes are poorly understood. This study leveraged genome-wide association data to examine the shared genetic architecture between multidimensional pain (MP), capturing broad genetic liability to chronic pain (

Identifiers

PMID42281971
PMCPMC13252582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.