ArticleWorld journal of transplantation2026
Impact of dexmedetomidine administration on serum creatinine levels following liver transplantation: A systematic review and meta-analysis.
Article in World journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIncidence of acute kidney injury (AKI), reflected by raised serum creatinine level, is a common complication following liver transplant. Dexmedetomidine, an α2-adrenergic agonist, has been proposed as a potential renoprotective agent in the preoperative/perioperative setting. However, its effects on renal outcomes after liver transplantation are relatively understudied.
aimTo assess the outcomes of preoperative/perioperative dexmedetomidine on serum creatinine level following liver transplant.
methodsThis systematic review evaluated studies investigating the outcome of preoperative/perioperative systemic dexmedetomidine on postoperative serum creatinine levels following liver transplant. Meta-analysis was performed using random or fixed effects models depending on the degree of statistical heterogeneity. Risk of bias and overall quality of evidence were assessed using standardized methodologies.
resultsA total of four studies involving 535 participants (of whom 270 received dexmedetomidine and 265 served as controls) were included in the meta-analysis. Preoperative/perioperative administration of dexmedetomidine was associated with a statistically significant reduction in postoperative serum creatinine levels (mean difference: -0.06 mg/dL; 95%CI: -0.09 to -0.02;
conclusionPreoperative/perioperative administration of dexmedetomidine was linked to a modest yet statistically significant decrease in postoperative serum creatinine levels after liver transplantation. Although these results suggest a possible biochemical effect, the clinical relevance remains uncertain, as no consistent improvement in clinically meaningful renal outcomes was demonstrated.
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