Evidence map›Paper›PMID 42281868›Full record

ReviewWorld journal of transplantation2026

Stem cell transplantation in head and neck oncology: Integrating oncologic treatment and maxillofacial reconstruction.

Marco Zeppieri, Matteo Capobianco, Federico Visalli, Marieme Khouyyi, Caterina Gagliano, Francesco Cappellani, Massimo Robiony, Alessandro Tel, Luca Michelutti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marco ZeppieriDepartment of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Matteo CapobiancoEye Clinic, Policlinico G. Rodolico, University of Catania, Catania 95121, Italy.
Federico VisalliDepartment of Ophthalmology, University of Catania, Catania 95123, Italy.
Marieme KhouyyiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina 98121, Italy.
Caterina GaglianoDepartment of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy.
Francesco CappellaniDepartment of Medicine and Surgery, University of Enna "Kore", Enna 94100, Italy.
Massimo RobionyDepartment of Maxillofacial Surgery, Department of Medicine, University of Udine, Udine 33100, Italy.
Alessandro TelClinic of Maxillofacial Surgery, Department of Head-Neck and Neurosciences, University Hospital of Udine, Udine 33100, Italy.
Luca MicheluttiClinic of Maxillofacial Surgery, Department of Head-Neck and Neurosciences, University Hospital of Udine, Udine 33100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck malignancies are aggressive, have complex anatomical placements, and require extensive surgical intervention for functional and cosmetic reasons. Recent advances in stem cell biology have expanded our understanding of their activities beyond oncogenic pathways to encompass tissue repair and regeneration. Mesenchymal and pluripotent stem cells have been studied for their immunomodulatory, microenvironmental, and bone and soft-tissue regeneration abilities following oncologic resection. Stem cells can connect oncologic treatment with reconstructive surgery, as shown in this narrative assessment of recent translational and regenerative advances in head and neck oncology. Autologous and allogeneic stem cell-based approaches, often combined with bioengineered scaffolds, have been shown to improve vascularization and functional restoration in complex craniofacial structures. Despite these promising advances, worries about tumor recurrence, stem cell plasticity, and the carcinogenic dangers of introducing stem cell-derived or growth-factor-enriched materials into previously treated or irradiated areas persist. In addition, regulatory, ethical, and scientific barriers prevent the widespread use of stem cell-based therapies in clinical oncology. Stem cell-centered research can transform head and neck cancer treatment from survival-focused to holistic oncological and functional rehabilitation that improves lifespan and quality of life by integrating regenerative science with precision surgery.

Indexed as

Head and neck oncologyMaxillofacial reconstruction tissue engineeringMesenchymal stem cellsRegenerative medicineStem cells

Identifiers

PMID42281868
PMCPMC13248171

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.