ArticleCureus2026
Concurrent Gastrointestinal Perforation and Cardiopulmonary Arrest in Toxic Epidermal Necrolysis: A Case of Profound Multi-organ Involvement.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Toxic epidermal necrolysis (TEN) is a serious, life-threatening cutaneous adverse reaction whose prevalence is widespread epidermal necrosis and detachment, mostly initiated by an adverse drug reaction. Muco-cutaneous manifestation is well-known, but severe systemic complications, specifically gastrointestinal complications and cardiac events, are extremely uncommon, with few cases reported in the literature. This case describes a 27-year-old man who was diagnosed with TEN after taking ibuprofen. He had colonic perforation and cardiopulmonary arrest despite systemic therapies and a multidisciplinary approach. The case study shows that even though TEN is associated with poor prognosis, there are rare serious complications, which are likely to be mediated in this case by the excessive systemic inflammatory response and coagulopathy due to sepsis, and have detrimental outcomes. These unusual complications must be detected early and dealt with aggressively to enhance patient survival in severe TEN.
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