ReviewMissouri medicine
Beyond COSS: The Evolution of Hemodynamic Imaging and Revascularization Strategies in Chronic Cerebrovascular Occlusion.
Review in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic carotid occlusion (CCO) carries a significant risk of ischemic stroke, particularly in patients with impaired cerebrovascular reserve. Extracranial-intracranial (EC-IC) bypass emerged as a popular treatment strategy with high technical success rates. However, multiple large randomized trials, including the Carotid Occlusion Surgery Study (COSS), failed to demonstrate a statistically significant benefit, mainly due to perioperative stroke risk and limitations in patient selection. Surgical revascularization declined as a result. We aim through this review to re-examine the role of flow augmentation in CCO in light of modern advances in cerebral perfusion imaging. Contemporary modalities-including computed tomography perfusion and emerging magnetic resonance techniques-allow better identification of patients with hemodynamic compromise who may be at highest risk despite medical therapy. Future studies incorporating refined imaging criteria may better define the subset of patients most likely to benefit from selective revascularization.
Indexed as
Identifiers
42281628PMC13252878What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.