Evidence map›Paper›PMID 42281589›Full record

ArticleHealth science reports2026

Performance of Large Language Models in Answering Healthcare Delivery Questions: A Quantitative Cross-Sectional Study.

Mohsen Khosravi, Zahra Zamaninasab, Fatemeh Khosravi, Melika Attar, Morteza Arab-Zozani

Abstract read
In one paragraph

Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohsen KhosraviSocial Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran.ORCID https://orcid.org/0000-0002-0576-7660
Zahra ZamaninasabDepartment of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran.
Fatemeh KhosraviSchool of Medicine Guilan University of Medical Sciences Rasht Iran.
Melika AttarSchool of Rehabilitation Sciences Babol University of Medical Sciences Babol Iran.
Morteza Arab-ZozaniSocial Determinants of Health Research Center Birjand University of Medical Sciences Birjand Iran.ORCID https://orcid.org/0000-0001-7223-6707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: The use of Large Language Model (LLM)-based chatbots across various fields has yielded positive outcomes. Understanding the health service delivery system offers numerous benefits. This study aimed to analyze the performance of LLMs in answering healthcare delivery questions. Methods: A validated questionnaire relevant to the research context was administered to a sample of LLM-based chatbots. The chatbots evaluated in this study included GPT-4.1-mini, Gemini 2.5, Copilot 2025, and Perplexity. A written prompt was provided to facilitate response generation by the chatbots. To analyze and compare the performance of the AI models in addressing the research questions, confusion matrices were constructed, and key metrics-sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy-were calculated. Results: The initial assessment of the chatbots showed perfect sensitivity (1.00), accurately identifying all true positives without false negatives. Specificity varied, with ChatGPT and Perplexity at 0.50, Gemini at 0.43, and Copilot at 0.33. Positive predictive values (PPV) ranged from 0.67 (Gemini) to 0.75 (ChatGPT and Perplexity), while negative predictive values (NPV) were uniformly perfect (1.00). Overall accuracy was highest for ChatGPT and Perplexity (0.80), with Gemini and Copilot at 0.73. In the second round, sensitivity remained perfect for all chatbots. Gemini achieved the highest specificity (0.80), followed by ChatGPT (0.67), Perplexity (0.60), and Copilot (0.50). PPVs improved, ranging from 0.75 (Copilot) to 0.91 (Gemini). NPVs remained perfect (1.00) across all models. Overall accuracy led by Gemini (0.93), with ChatGPT and Perplexity both at 0.87, and Copilot at 0.80. Conclusion: ChatGPT and Perplexity showed the highest initial performance, while the second round revealed improvements in most chatbots, especially in specificity and accuracy, with Gemini performing best. Further research is needed for deeper insights.

Indexed as

artificial intelligencedelivery of health careeducationgenerative artificial intelligencelarge language models

Identifiers

PMID42281589
PMCPMC13250468

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.