ArticleHealth science reports2026
Relationship of Genetic Variability (
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background and Aims: Frequent blood donation can significantly increase the risk of iron deficiency, influenced by demographic, dietary, environmental, and genetic factors. This study aims to evaluate the association between iron deficiency and specific genetic variations ( Methods: This cross-sectional study was conducted at the Iranian Blood Transfusion Organization (IBTO) between March and September 2023, targeting male donors registered as regular donors in the database (with a minimum of two donations in the past year and at least five donations over the past 3 years) aged 18-65. Strict inclusion criteria were applied to minimize potential confounding variables. To investigate genetic polymorphisms, we utilized techniques such as Sanger sequencing, allele-specific PCR, and high-resolution melt (HRM) analysis. Iron status was assessed by measuring key biochemical indicators-serum ferritin, Iron, transferrin saturation (TSAT), and total iron-binding capacity (TIBC)-through ELISA and colorimetric assays. Statistical analyses were performed using R software (version 4.1.1). Methods included one-way ANOVA, the Kruskal-Wallis test, the Shapiro-Wilk test, and independent samples Results: The rs11549465 polymorphism in Conclusion: Genetic screening for the rs11549465 polymorphism could be integrated into donor management programs to personalize strategies for mitigating Iron deficiency risks. Additional research involving larger and more diverse groups is necessary to investigate interactions between genetic, dietary, and environmental factors.
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