ArticleVeterinary medicine and science2026
Comparative Effects of Laparotomy and Laparoscopy-Assisted Embryo Transfer on Oxidative Stress and Thiol-Disulphide Homeostasis in Tuj Ewes.
Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesIn this study, it was aimed to compare the effects of embryo transfer performed via laparotomy and laparoscopy on thiol-disulphide homeostasis and some oxidative stress markers in Tuj ewes.
methodsIn the study, 10 Tuj ewes were randomly divided into two groups (laparotomy, n = 5; laparoscopy, n = 5). A progesterone-based synchronization protocol was applied to all animals. Blood samples were collected immediately before surgery, immediately after surgery, and at 24 and 48 h postoperatively. Serum levels of glutathione (GSH), malondialdehyde (MDA), total thiol (TT), native thiol (NT), disulphide (Ds) and thiol-disulphide ratios were determined.
resultsGroup, time, and group × time interactions were found to be statistically significant for GSH, MDA, TT, and NT parameters (p < 0.05). In the laparotomy group, GSH, TT, and NT levels markedly decreased during the postoperative period (p < 0.05), whereas MDA levels showed a significant increase, particularly at 48 h (p < 0.05). In the laparoscopy group, changes in oxidative stress markers were found to be more limited. Although no significant differences were observed between the groups in terms of disulphide levels and thiol-disulphide ratios (p > 0.05), time-dependent changes in these parameters were statistically significant (p < 0.05). In the laparotomy group, significant negative correlations were detected between MDA and antioxidant parameters (p < 0.05), while strong positive correlations were observed among thiol parameters (p < 0.01).
conclusionsAs a result, it was concluded that the surgical approach used in embryo transfer affects the systemic oxidative stress response and that thiol-disulphide homeostasis can be considered a sensitive biomarker for revealing these differences. It was determined that the laparoscopic embryo transfer method disrupts redox balance to a lesser extent and better preserves the antioxidant defence system compared with laparotomy.
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