Evidence map›Paper›PMID 42281384›Full record

Trial reportPhysiological reports2026

The acute respiratory response to blood-flow restriction resistance exercise in healthy adults: A randomized crossover trial.

Manuel Kuhn, Dario Kohlbrenner, Adrian Kläy, Malcolm Kohler, Alea Gheza, Laura C Mayer, Thomas Radtke, Sarah R Haile, Diego M Baur, Noriane A Sievi and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuel KuhnFaculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-1483-1318
Dario KohlbrennerFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Adrian KläyDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Malcolm KohlerFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Alea GhezaFaculty of Medicine, University of Zurich, Zurich, Switzerland.
Laura C MayerDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Thomas RadtkeEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Sarah R HaileEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Diego M BaurDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Noriane A SieviDepartment of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
Christian F ClarenbachFaculty of Medicine, University of Zurich, Zurich, Switzerland.

Funding

Heubergstiftung (Heuberg Stiftung) 09-2022Lung Zurich 2021-03
6 · The paper itself

Abstract

This study compared acute respiratory responses to low-load blood flow restriction resistance exercise (LL-BFR) and traditional high-load resistance exercise (HL-TRA) in healthy individuals. A randomized crossover design with a 48-h washout was used. Participants completed LL-BFR (30% one repetition maximum [1RM], 70% limb occlusion pressure [LOP]) and HL-TRA (70% 1RM, no occlusion) on a leg press. HL-TRA involved 3 sets of 12 repetitions; LL-BFR included 4 sets (15, 30). Respiratory parameters were measured breath-by-breath. Ratings of perceived breathing effort and leg exertion (0-10 scale) were recorded. Data were analyzed using linear mixed models. Twenty-four participants (8 males, 16 females) completed the study. LL-BFR resulted in lower minute ventilation (VE, primary outcome) by -3.32 L/min (95% CI: -4.55 to -2.08), oxygen consumption by -0.12 L/min (95% CI: -0.15 to -0.09), carbon dioxide production by -0.16 L/min (95% CI: -0.19 to -0.13), and perceived breathing effort by -1.2 units (95% CI: -1.5 to -0.8) compared to HL-TRA. Perceived leg exertion was higher with LL-BFR (1.8 units; 95% CI: 1.3 to 2.2). LL-BFR elicited lower respiratory responses and reduced perceived breathing effort than HL-TRA, despite greater leg discomfort.

Indexed as

Muscle, SkeletalRegional Blood FlowResistance TrainingRespirationAdultCross-Over StudiesFemaleHumansMaleOxygen ConsumptionPhysical ExertionYoung Adultblood flow restrictionhealthy individualsrespiratory responsestrength exercise

Identifiers

PMID42281384
PMCPMC13261080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.