Evidence map›Paper›PMID 42281337›Full record

ArticleChembiochem : a European journal of chemical biology2026

Semi-Rational Engineering of Formate Dehydrogenase Reveals Loop Dynamics as a Key Determinant of Thermostability.

Rattima Boonkumkrong, Sahachat Soithongcharoen, Pitchayathida Mee-Udorn, Paweenapon Chunthaboon, Somchart Maenpuen, Thanyada Rungrotmongkol, Pratchaya Watthaisong, Ruchanok Tinikul

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rattima BoonkumkrongDepartment of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Sahachat SoithongcharoenDepartment of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Pitchayathida Mee-UdornInvestment Promotion Division 1, Thailand Board of Investment (BOI), Bangkok, Thailand.
Paweenapon ChunthaboonDepartment of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Somchart MaenpuenDepartment of Biochemistry, Faculty of Science, Burapha University, Chonburi, Thailand.
Thanyada RungrotmongkolCenter of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Pratchaya WatthaisongSchool of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, Thailand.
Ruchanok TinikulDepartment of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0001-6654-7066

Funding

Burapha UniversityCentral Instrument FacilityDevelopment and Promotion of Science and Technology Talent ProjectFaculty of ScienceMahidol University N42A680374Mahidol University to RT N42A680374National Research Council of Thailand (NRCT) N42A680374Thai government scholarship (DPST)Vidyasirimedhi Institute of Science and Technology
6 · The paper itself

Abstract

Formate dehydrogenase (FDH) catalyzes the reversible formate oxidation using NAD

Indexed as

Formate DehydrogenasesProtein EngineeringTemperatureBacillusBiocatalysisEnzyme StabilityMolecular Dynamics SimulationFormate Dehydrogenasesbiocatalysiscofactor regenerationenzyme engineeringformate dehydrogenasethermostability

Identifiers

PMID42281337
PMCPMC13261307

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.