Evidence map›Paper›PMID 42281331›Full record

ArticleAndrology2026

ClpP Ensures Mitochondrial Integrity and Spermatocyte Meiotic Progression in Mice.

Hai-Wei Feng, Yan-Lin Gao, Bin-Jie Jiang, Muhammad Zubair, Dong-Teng Liu, Zhi-Shen Xu, Zheng-Zhu Wang, Hong-Ling Wang, Xue-Mei Wang, Jing-Xia Sun and 2 more

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In one paragraph

Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hai-Wei FengGuangdong Key Laboratory of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yan-Lin GaoMaternal-Fetal Medicine Institute, Department of Obstetrics and Gynecology, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
Bin-Jie JiangShenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Muhammad ZubairDepartment of Reproductive Health and Infertility, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Dong-Teng LiuShenzhen Key Laboratory of Fertility Regulation, Reproductive Medicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Zhi-Shen XuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.ORCID https://orcid.org/0000-0003-3754-9868
Zheng-Zhu WangDepartment of Reproductive Health and Infertility, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Hong-Ling WangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Xue-Mei WangDepartment of Reproductive Health and Infertility, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Jing-Xia SunGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Guo-Hua ZengGuangdong Key Laboratory of Urology, Department of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-3790-6434
Li-Jun HuoBiomedical Research Institute, Hubei University of Medicine, Shiyan, China.ORCID https://orcid.org/0000-0002-9479-2218

Funding

Hong Kong Research Grant Council 17114920Hubei University of Medicine 2025QDJZR01National Natural Science Foundation of ChinaShenzhen Science and Technology Program of China KQTD20190929172749226Swedish Research Council Collaboration Research Program NSFC-VR 8211101255the Shenzhen Fundamental Research Program JCYJ20220530154805013
6 · The paper itself

Abstract

backgroundCaseinolytic peptidase P (ClpP) plays a key role in maintaining cellular homeostasis for mitochondrial quality control. However, the specific function of ClpP during meiosis and its subcellular localization in spermatocytes remain poorly understood.

objectiveTo investigate the function of ClpP in spermatocyte meiosis. MATERIALS AND

methodsClpP expression was examined in mouse spermatocytes, and tamoxifen was utilized to achieve spatiotemporal-specific deletion of Clpp mediated by Ddx4-Cre

resultsA progressive increase in ClpP expression levels was evident from the leptotene stage to the pachytene stage in mouse spermatocytes, and a decrease in ClpP expression was observed from the diplotene stage to the metaphase I (MI) stage. Compared with wild-type male mice, adult Clpp

conclusionsClpP is critical for spermatocyte survival and mitochondrial integrity during meiosis. As a consequence of its deficiency, meiotic progression and spermatogenesis are disrupted, highlighting its essential role in the meiosis of spermatocytes.

Indexed as

Endopeptidase ClpMeiosisMitochondriaSpermatocytesSpermatogenesisAnimalsMaleMiceMice, KnockoutCLPP protein, mouseEndopeptidase ClpClpPmeiotic recombinationmitochondrial morphologyspermatogenesis

Identifiers

PMID42281331
PMCPMC13432486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.