Evidence map›Paper›PMID 42281295›Full record

SynthesisImmunity, inflammation and disease2026

Severe Abdominal Pain as a Prominent Clinical Manifestation of Anti-DPPX Autoimmune Encephalitis: A Case Report and Systematic Review.

Difang Shi, Haohao Wu, Baogang Huang, Yan Zheng, Jia Liu, Jianjian Bao, Fengming Xu, Kang Du

Abstract readCase ReportsSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Difang ShiDepartment of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.ORCID https://orcid.org/0009-0009-9252-4816
Haohao WuDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Baogang HuangDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Yan ZhengDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Jia LiuDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Jianjian BaoDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Fengming XuDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.
Kang DuDepartment of Neurology, Yunnan Qujing Central Hospital (Qujing First People's Hospital), Qujing, Yunnan, China.

Funding

Scientific Research Project of Qujing First People's Hospital in 2023 2023YJKTB02
6 · The paper itself

Abstract

backgroundAnti-dipeptidyl-peptidase-like protein 6 encephalitis (DPPXE) is an exceptionally rare form of autoimmune encephalitis characterized by a highly heterogeneous clinical phenotype.

methodsIn this study, we report a Chinese patient presenting with severe abdominal pain as a prominent symptom; furthermore, we conducted a systematic review and analysis of 125 cases of DPPXE (including the present case).

resultsThis rare case presented with severe abdominal pain as a prominent symptom. We comprehensively summarized the clinical presentations, patterns of recurrence, and therapeutic responses of DPPXE. Notably, by comparing the clinical characteristics of DPPXE cases reported in China with those from other regions, we found some differences in disease presentation, suggesting potential racial or geographic variability.

conclusionOur findings may provide up-to-date and comprehensive insights into the pathophysiology and clinical course of this rare disorder from multiple perspectives.

Indexed as

Abdominal PainAutoantibodiesDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEncephalitisAdolescentHumansMaleNerve Tissue ProteinsPotassium ChannelsAutoantibodiesDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDPP6 protein, humanNerve Tissue ProteinsPotassium Channelsautoimmune encephalitiscase reportDPPXliterature reviewsevere abdominal pain

Identifiers

PMID42281295
PMCPMC13260868

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.