ArticleThe Journal of infectious diseases2026
People With Prior Tuberculosis Have Accelerated Frailty and Differential Survival into Older Age: A Cross-sectional Analysis in Southern Africa.
M Coleman, A Manyara, C J Calderwood, A de Wilton, E I Y Madela, H Wilson, A Burton, L Gates, B Cassim, C Pearse and 5 more
Abstract read
In one paragraphArticle in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
M ColemanSydney Infectious Diseases Institute, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4414-5645 A ManyaraGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-6276-926X C J CalderwoodClinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
A de WiltonGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-3363-8372 E I Y MadelaDepartment of Geriatrics, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.ORCID 0000-0003-0043-3853 H WilsonGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-0297-8259 A BurtonGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-4416-0538 L GatesMRC Lifecourse Epidemiology Centre, Human Development and Health, University of Southampton, Southampton, United Kingdom.
B CassimDepartment of Geriatrics, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.
C PearseMRC Lifecourse Epidemiology Centre, Human Development and Health, University of Southampton, Southampton, United Kingdom.
T MadanhireGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-2449-0027 R A FerrandClinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0002-7660-9176 K A WardMRC Lifecourse Epidemiology Centre, Human Development and Health, University of Southampton, Southampton, United Kingdom.
K KranzerInstitute of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0001-5691-7270 C L GregsonGlobal Health and Ageing Research Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-6414-0529 Funding
Medical Research Council Musculoskeletal Functional Ability in Sub-Saharan Africa MR/W003961/1National Institute for Health Research 217135/Z/19/ZNational Institute for Health Research NIHR302394Wellcome 225466/Z/22/ZWellcome Trust
6 · The paper itselfAbstract
Post-tuberculosis disability impairs quality-of-life, yet chronic functional outcomes for tuberculosis survivors remain under-characterized. This cross-sectional sub-study (2022-2024) estimated Fried frailty phenotype prevalence among adults aged ≥40 years with self-reported prior tuberculosis in South Africa and Zimbabwe, compared with those with no tuberculosis history. Survivor bias was evaluated using historic WHO data. After adjusting for age, sex, education, HIV, diabetes and socioeconomic factors, prior tuberculosis was associated with twice the odds of frailty (OR = 2.06, 95% CI 1.38-3.03, P = .001), and worse survival into older age. As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age.
Indexed as
FrailtyTuberculosisAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeSouth AfricaZimbabwefrailtyhealthy ageingmultimorbiditypost-TBtuberculosis
Identifiers
PMID42281267
PMCPMC13668369
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