ArticlePolymers2026
Eco-Friendly Selenium-Hyaluronic Acid Nanoconjugates with Potent Anticancer, Antimicrobial, Anti-Inflammatory and Wound-Healing Activities.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Cancer and multidrug-resistant microbial infections remain major global health challenges, underscoring the need for multifunctional, biocompatible, and environmentally sustainable therapeutic platforms. Herein, selenium-hyaluronic acid nanoconjugates (Se/HA NPs) were synthesized through an eco-friendly ascorbic acid-mediated reduction approach to improve the bio-functional stability and therapeutic performance of selenium-based nanomaterials. The formation of Se/HA NPs was confirmed by transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), and Fourier-transform infrared spectroscopy (FTIR). FTIR analysis supported the involvement of ascorbic acid- and hyaluronic acid-associated functional groups in nanoparticle formation and stabilization. TEM revealed well-dispersed, predominantly spherical nanoparticles with diameters ranging from 29.72 to 80.38 nm, while XRD confirmed their crystalline nature with an average crystallite size of 31.2 nm. Biologically, Se/HA NPs exhibited strong antibacterial activity against
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